Complex coacervate tissue adhesives: effect of polycation chemistry and ionic strength on cytocompatibility.

ABSTRACT: Tissue adhesives are regularly used for wound healing, bleeding control and sealing internal organ leakages. However, currently available tissue adhesives are often cytotoxic. Polycations containing primary amines are generally known to induce cytotoxicity. Complex coacervates, composed of oppositely charged polyelectrolytes, may offer a biocompatible alternative. In this study, primary amines of polyallylamine hydrochloride (pAH) were reacted with glycidyltrimethylammonium chloride (GTMAC) following an epoxide ring nucleophilic substitution to obtain pAH with quaternary ammonium pendant groups (q-pAH). These polycations were combined with negatively charged polysulfopropyl methacrylate (pSPMA) to form complex coacervates. The biocompatibility of the individual polyelectrolytes and resulti

SUBMITTER: Kwant AN 

PROVIDER: S-EPMC12783172 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature