A cross-sectional study on the effects of intravesical BCG on urinary microbiota in bladder cancer patients.

ABSTRACT:

Background

Urinary bladder cancer is among the most common malignancy worldwide. Despite surgical interventions and regular surveillance, recurrence and progression to advanced disease are observed in patients. Intravesical administration of Bacillus Calmette-Guérin (BCG) could reduce bladder cancer recurrence and progression in patients with intermediate- and high-risk non-muscle-invasive bladder cancer (NMIBC). Nonetheless, not all patients respond well to BCG treatment. We aim to evaluate whether bacteria profiles were altered after BCG administration.

Methods

In this cross-sectional study, we investigate the differences in urinary microbiome between non-cancerous controls, bladder cancer patients undergoing surveillance cystoscopy, and patients with BCG administration (p

SUBMITTER: Li JKM 

PROVIDER: S-EPMC12783175 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature