How is Levetiracetam Monotherapy Currently Monitored in Pregnancy? A Systematic Review.

ABSTRACT:

Background

Levetiracetam is commonly used as antiepileptic drug during pregnancy and has a well-established safety profile in that setting. Pregnancy-related pharmacokinetic changes may result in decreased levetiracetam levels and increased seizure frequency during pregnancy. Therapeutic drug monitoring (TDM) of levetiracetam levels may facilitate dose adjustment. Although levetiracetam TDM is widely used in pregnancy, robust guidelines are still lacking, resulting in heterogeneous use of TDM.

Objectives

The aim of this review was to provide insight into levetiracetam TDM strategies utilised during pregnancy.

Methods

A systematic search up to 17 April 2025 was carried out using MEDLINE, Embase, APA PsycINFO, and Cochrane Central Register of Controlled Trials through O

SUBMITTER: Rademaker T 

PROVIDER: S-EPMC12783189 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature