A Study on dynamic functional connectivity and efficacy prediction of SAINT for rapid antidepressant effects and relief of suicidal ideation.

ABSTRACT: Repetitive transcranial magnetic stimulation (rTMS) is widely used in the treatment of major depressive disorder (MDD). Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) is currently the latest effective treatment option that can rapidly antidepressant and alleviate suicidal ideation. However, its mechanism of action is unclear. In this study, we applied regional homogeneity (ReHo) and dynamic functional connectivity (DFC) analyses to investigate the temporal similarity of signal fluctuations and dynamic properties of functional connectivity in 26 MDD patients. ReHo analysis revealed alterations of synchronicity of neuronal oscillations after treatment in the default mode network, subcutaneous nucleus network, frontoparietal network, etc. DFC analysis showed that there were

SUBMITTER: Zhai W 

PROVIDER: S-EPMC12783197 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature