Liver fibrosis index and mortality in metabolic dysfunction-associated steatotic liver disease: a Korean cohort study.

ABSTRACT: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major public health concern. However, its relationship with the long-term mortality risk remains underexplored in the general population. We aimed to examine the association between liver fibrosis, assessed using the age-adjusted Fibrosis-4 (FIB-4) residual index, and all-cause and cardiovascular mortality in individuals with MASLD. This cohort study included 134,686 adults diagnosed with MASLD via ultrasonography and metabolic abnormalities during health screenings at two Korean centers between 2002 and 2022. The participants were followed up for mortality outcomes using the National Death Registry. The FIB-4 index was calculated from age, AST, ALT, and platelet count adjusted for age using residual modeling. Cox propor

SUBMITTER: Lee Y 

PROVIDER: S-EPMC12783302 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature