Informative simultaneous confidence intervals for graphical test procedures.

ABSTRACT: Simultaneous confidence intervals that are compatible with a given closed test procedure are often non-informative. More precisely, for a one-sided null hypothesis, the bound of the simultaneous confidence interval can stick to the border of the null hypothesis, irrespective of how far the point estimate deviates from the null hypothesis. This has been illustrated for the Bonferroni-Holm and fall-back procedures, for which alternative simultaneous confidence intervals have been suggested, that are free of this deficiency. These informative simultaneous confidence intervals are not fully compatible with the initial multiple test, but are close to it and hence provide similar power advantages. They provide a multiple hypothesis test with strong family wise error rate control that can be used

SUBMITTER: Brannath W 

PROVIDER: S-EPMC12783375 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature