Aglodorols A-J, undescribed terpenoids with multidimensional neuroprotective activities from Aglaia odorata Lour.

ABSTRACT: Three unprecedented triterpenoids (1-2, 8), seven novel diterpenoids (13-16, 19-21), and 12 known compounds (3-7, 9-12, 17-18, 22) were isolated from the tender branches and leaves of Aglaia odorata Lour. Structural elucidation was achieved through integrated spectroscopic analysis, quantum chemical calculations (NMR/ECD), and single-crystal X-ray diffraction. All isolates were evaluated for neuroprotective effects. Compounds 3, 9-11, 13, 17, and 18 showed significant protective effects against oxygen-glucose deprivation/reperfusion (OGD/R)-mediated nerve injury in PC12 cells at 10 µM, while compounds 3 and 19 exhibited potent anti-excitotoxicity activity in the L-glutamate-induced HT22 cells at 20 µM. Strikingly, triterpenoids 1, 2, and 11 displayed remarkable activity against RSL3-induce

SUBMITTER: Ding M 

PROVIDER: S-EPMC12783399 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature