Analysis of clinicopathological features, treatment modalities, and survival outcomes in advanced gastric and colorectal signet ring cell carcinoma.

ABSTRACT:

Background

Advanced gastric and colorectal signet ring cell carcinoma (SRCC) exhibit distinct biological behaviors, yet comprehensive characterization of their clinicopathological features, treatment modalities, and survival disparities remains limited. Leveraging the Surveillance, Epidemiology, and End Results (SEER) database, this population-based study aimed to elucidate these critical aspects.

Methods

We retrospectively analyzed 15,214 patients with American Joint Committee on Cancer (AJCC) stage III/IV gastric (n = 10,203) or colorectal (n = 5011) SRCC diagnosed between 2000 and 2021. Clinicopathological characteristics and survival outcomes were compared across cohorts. Four treatment modalities were evaluated: surgery alone, chemotherapy (CT) alone, surgery + CT, and

SUBMITTER: Xu J 

PROVIDER: S-EPMC12783405 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature