High-Dose Minocycline Improves Outcomes in Acinetobacter baumannii Group Pneumonia: A Propensity-Weighted Cohort Study with MIC-Based Insights for Breakpoint Revision.

ABSTRACT:

Introduction

Optimal minocycline dosing for Acinetobacter baumannii group pneumonia remains unclear. We assessed the clinical impact of high-dose (HD) versus standard-dose (SD) minocycline and explored the predictive value of susceptibility breakpoints.

Methods

In this multicenter retrospective cohort study, hospitalized adults with AB group pneumonia treated with minocycline were classified into HD (200 mg IV q12h) or SD (100 mg IV q12h or 200 mg IV q24h) groups. Inverse probability of treatment weighting (IPTW) and multivariate logistic regression were applied to adjust for baseline differences. Kaplan-Meier survival and subgroup analyses were performed to evaluate dose-response effects and the utility of different minimum inhibitory concentration (MIC) breakpoints.

Res

SUBMITTER: Tseng YT 

PROVIDER: S-EPMC12783419 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature