Impact of Risk Stacking on COVID-19-Related Healthcare Utilization: A Real-World Retrospective Cohort Study.

ABSTRACT:

Introduction

This study evaluated the impact of "risk stacking" on COVID-19-related hospitalizations, emergency department/urgent care (ED/UC) visits, and outpatient visits among non-immunocompromised individuals aged 18-49 and 50-64 years compared with immunocompromised individuals and those ≥ 65 years.

Methods

Using Optum Clinformatics^® data, adults were assigned to ≥ 1 category based on underlying CDC-categorized high-risk (HR) conditions: HR-Conclusive (from which immunocompromising conditions were separated), HR-Suggestive, Mixed Evidence, No HR Conditions. The impact of multimorbidity quantities and HR categories on COVID-19 healthcare resource utilization (HCRU) was evaluated.

Results

Overall (n = 10,631,427), the most prevalent conditions were hyper

SUBMITTER: Ernst FR 

PROVIDER: S-EPMC12783426 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature