Clinical Impact of Implementing a Specific Clinical Pathway for the Management of Clostridioides difficile Infection.

ABSTRACT:

Introduction

Despite Clostridioides difficile infection (CDI) being a leading healthcare-associated infection with high morbimortality, there is little evidence on specific antimicrobial stewardship program (ASP) interventions for CDI. The objective of this study was to assess the clinical impact of implementing a specific clinical pathway for CDI management at two Spanish hospitals.

Methods

This was a quasi-experimental pre-post intervention study, and three periods were evaluated: historical (2014-2017), educational-ASP (2018-2020), and intervention (2021-2023), after implementation of a CDI-specific measures bundle. Key measures included: (1) updated local CDI guidelines; (2) 24/7 diagnostic testing and real-time positive results notification to ASP-CDI team; (3) systemat

SUBMITTER: Rodriguez-Fernandez M 

PROVIDER: S-EPMC12783481 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature