Epidemiology of Invasive Escherichia coli Disease in Adults Using Routine Healthcare Records from the United States, 2002-2022.

ABSTRACT:

Introduction

Extraintestinal pathogenic Escherichia coli can infect normally sterile body sites, causing invasive E. coli disease (IED). The IED burden is often underestimated. Here, we provide more insights into the real-world epidemiology of IED in the United States from 2002 to 2022.

Methods

In this retrospective cohort study, a narrow and a broad algorithm composed of coded diagnoses combined with laboratory data (microbiology culture) were first validated against the gold-standard IED case definition. The algorithms were selected to identify IED cases among adults in the Kaiser Permanente Northwest database. IED incidence rates (IRs) and case fatality rates (CFRs) were calculated and stratified by period, age, and sex. The risk of IED in the population with pre-defined

SUBMITTER: Schmidt MA 

PROVIDER: S-EPMC12783483 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature