Hemispheric Asymmetry in the Genetic Overlap between Schizophrenia and White Matter Microstructure.

ABSTRACT: White matter microstructure, essential for neural communication, is genetically influenced and often disrupted in schizophrenia. Large-scale genome-wide association studies have identified over 200 genome-wide significant loci for schizophrenia, yet the extent to which schizophrenia shares genetic architecture with white matter microstructure-particularly across multidimensional diffusion tensor imaging (DTI) metrics and hemispheric distinctions-remains incompletely understood. Here, we employed the conditional/conjunctional false discovery rate (cond/conjFDR) approach to investigate the genetic overlap between schizophrenia and white matter microstructure. These analyses utilized large-scale genome-wide association datasets for schizophrenia (N _case = 53,386, N

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12783525 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature