A Pseudomonas aeruginosa quorum-sensing inducer controls lung permeability in establishing chronic infection via EGFR.

ABSTRACT: Pseudomonas aeruginosa is an opportunistic pathogen that can cause severe infections in immunocompromised patients. N-(3-oxo-dodecanoyl) homoserine lactone (3oc12) is a small quorum molecule that is used to communicate between bacterial cells and between bacteria and the host. However, the exact molecular mechanisms of this exchange is not yet fully understood. Here, we present a modality that P. aeruginosa uses to finetune the severity of lung infection, where 3oc12 is incorporated into the host cell membrane, causing a marked increase in epidermal growth factor receptor (EGFR) ligand-independent self-dimerization. This ligand-free self-activation leads to epidermal growth factor receptor-signal transducer activator of transcription-3 (EGFR-STAT3) signaling, resulting in higher expression

SUBMITTER: Zheng M 

PROVIDER: S-EPMC12783613 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature