Oncogenic and immunological roles of NSUN2 in triple negative breast cancer.

ABSTRACT: Immunotherapy have led to clinical remissions in many solid tumors. However, the efficacy of immunotherapeutic monotherapy in triple-negative breast cancer (TNBC) is not very satisfactory. NSUN2 functions as a proto-oncogene in various cancers, promoting tumor cell proliferation, invasion, and metastasis. However, its role in modulating the tumor immune microenvironment, particularly in TNBC immunotherapy and its relationship with treatment sensitivity in TNBC remain to be further explored. In this study, we found that NSUN2 was highly expressed in pan-cancer, and elevated levels correlate with poor prognosis in TNBC. Furthermore, NSUN2 expression demonstrated a positive correlation with immune cell infiltration and the expression of immune checkpoint molecules. Up-regulated NSUN2 expressi

SUBMITTER: An N 

PROVIDER: S-EPMC12783637 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature