Increased axial resolution OCT improves structure-function correlation of the disorganization of the retinal inner layers in diabetic retinal disease.

ABSTRACT: This study aimed to determine whether optical coherence tomography (OCT) with enhanced axial resolution improves structural characterization of the disorganization of the retinal inner layers (DRIL) in diabetic retinal disease (DRD) and its association with functional and vascular alterations. In this prospective cross-sectional study, 55 diabetic patients, 27 with DRIL (age: 57.1 ± 14.6 years) and 28 eyes without DRIL with diabetes mellitus (DM) type I/II (age: 58.2 ± 13.0 years), were examined with conventional spectral-domain OCT (SD-OCT), High-Resolution (High-Res) OCT, OCT angiography (OCTA), and microperimetry. DRIL areas were significantly smaller on High-Res OCT compared to SD-OCT (mean ± standard deviation, 0.3 ± 0.3 vs. 1.3 ± 1.2 mm², p < 0.001). OCTA analyses demonstr

SUBMITTER: Wall K 

PROVIDER: S-EPMC12783662 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature