Context-Dependent Roles of ANGPTL2-Mediated Inflammaging in Tissue Homeostasis, Pathological Tissue Remodeling, and Longevity.

ABSTRACT: Chronic inflammation is a key driver of aging-related diseases, obesity-associated metabolic disorders, and tumor progression. Aging and obesity contribute to the accumulation of senescent cells, which secrete senescence-associated secretory phenotype (SASP) factors that promote tissue remodeling and chronic inflammation. Here, we investigated the pathological roles of angiopoietin-like protein 2 (ANGPTL2), a potential SASP factor, in a mouse model of high-fat diet-induced premature aging. We found that ANGPTL2 deficiency shortened lifespan but attenuated systemic inflammation, indicating a complex role for ANGPTL2 in aging-related processes. ANGPTL2 was required for maintaining intestinal homeostasis under metabolic stress; however, ANGPTL2 also exacerbated adipocyte hypertrophy and cardi

SUBMITTER: Yumoto S 

PROVIDER: S-EPMC12783698 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature