The Effect of Chronotherapy on Clinical Outcomes in Hypertensive Patients: A Systematic Review and Meta-Analysis Comparing Bedtime Versus Morning Dosing of Antihypertensive Drugs.

ABSTRACT:

Background and aims

This systematic review and meta-analysis aimed to compare the clinical outcomes of antihypertensive medication administration at bedtime versus morning, focusing on major adverse cardiovascular events (MACE), mortality, and secondary cardiovascular outcomes in hypertensive patients.

Methods

We conducted a systematic search across multiple databases to identify randomized controlled trials (RCTs) comparing bedtime versus morning antihypertensive dosing. Studies were included if they evaluated MACE, all-cause mortality, or cardiovascular mortality. Myocardial infarction, stroke, and heart failure were considered secondary outcomes. Data were extracted, and statistical analysis was performed using hazard ratios and mean differences with 95% confidence interv

SUBMITTER: Azami P 

PROVIDER: S-EPMC12783704 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature