Trajectory analysis of BMI increase induced by second-generation antipsychotics in first-episode schizophrenia: a secondary analysis based on CNFEST***.

ABSTRACT: Antipsychotic-induced weight gain (AIWG) exhibits marked heterogeneity. We conducted a secondary analysis of the Chinese First-Episode Schizophrenia Trial, leveraging frequent body mass index (BMI) measurements over 12 months. Our aims were to identify latent BMI trajectories in first-episode schizophrenia (FES) patients treated with second-generation antipsychotics (SGAs) and to explore predictors of trajectory membership. Subjects in this study were from the Chinese First-Episode Schizophrenia Trial (CNFEST). After quality control, a total of 361 drug-naïve FES patients treated with olanzapine, risperidone, or aripiprazole were included. BMI was measured at 7 timepoints over 12 months. Latent class trajectory modeling (LCTM) was used to identify distinct BMI trajectories. Multinomial log

SUBMITTER: Yin X 

PROVIDER: S-EPMC12783731 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature