Relationship between hippocampal volume and treatment response before and after escitalopram administration in patients with depression.

ABSTRACT: The hippocampus plays a crucial role in memory formation and emotional regulation, and is closely related to the pathology of depression. Escitalopram, a selective serotonin reuptake inhibitor, promotes neurogenesis in the dentate gyrus of the hippocampus and alters its structure. This study examined the relationship between these escitalopram-induced structural changes and treatment response in 107 patients with moderate to severe depression, of whom 56 were female (52.3%), with a mean age of 41.5 years (range: 25-73 years). Follow-up data were available for 71 patients (66.4%). Changes in the volume and laterality of hippocampal subregions were compared before and after escitalopram treatment between Responders to escitalopram (n = 53) and Nonresponders (n = 54). The results indicated th

SUBMITTER: Kamishikiryo T 

PROVIDER: S-EPMC12783789 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature