Exosome-transmitted long noncoding RNA SNHG1 promotes prostate cancer bone metastasis via YBX1/MMP16 axis.

ABSTRACT: Prostate cancer (PCa) patients with bone metastasis commonly exhibit osteoblastic-type and have an extremely poor prognosis. Exosomes derived from tumor cells possess biological significance and can mediate intercellular communication in the tumor microenvironment. Long noncoding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) is implicated in tumorigenesis and the development of PCa, but the precise roles of SNHG1 in the regulation of bone homeostasis remain elusive. Herein, we aimed to investigate the underlying mechanisms by which exosomes-encapsulated SNHG1 affects the bone metastasis of PCa. Our findings revealed that SNHG1 was overexpressed in PCa tissues, highly enriched in PCa cell-derived exosomes, and positively correlated with bone metastasis. Besides, SNHG1 shuttled by PCa

SUBMITTER: Yang T 

PROVIDER: S-EPMC12783806 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature