CUN‑BAE predicts risk of metabolic dysfunction-associated steatotic liver disease: A prospective cohort study in non‑obese Chinese adults.

ABSTRACT: While metabolic dysfunction-associated steatotic liver disease (MASLD) increasingly affects non-obese individuals, current screening approaches show poor performance in this population. We investigated whether the Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) could better identify MASLD risk than traditional measures in non-obese adults, and examined how the triglyceride-glucose (TyG) index might mediate this relationship. Using data from the Dryad public database, we followed 16,173 Chinese non-obese adults (BMI < 25 kg/m²) without baseline MASLD for 5 years. MASLD diagnosis relied on abdominal ultrasonography. We applied multivariable logistic regression to assess cross-sectional associations and Cox models for incident disease risk. Restricted cubic splines revealed

SUBMITTER: Wu X 

PROVIDER: S-EPMC12783850 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature