Regional disparities in cerebral perfusion and brain tissue microstructure damage in adult patients with Moyamoya syndrome.

ABSTRACT: In Moyamoya syndrome (MMS), cerebral perfusion and tissue microstructure are impaired, but regional differences remain unclear. This study analyzed 22 adult MMS patients using CT perfusion (CTP) and intravoxel incoherent motion (IVIM). All hemispheres were classified into four ischemia grades based on symptoms and imaging. CTP parameters (CBF, CBV, MTT, TTP) and IVIM parameters (ADC, D, D*, f) were measured in the temporal lobe and basal ganglia. The relative values of CTP parameters and absolute values of IVIM parameters were compared across hemispheres with different ischemia grades. Additionally, correlation analyses were conducted between CTP and IVIM parameters. Results showed that in the temporal lobe, rMTT and rTTP were significantly increased (p = 0.018 and 0.002, respectively) wit

SUBMITTER: Gao L 

PROVIDER: S-EPMC12783861 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature