Staphylococcal SplA and SplB Serine Protease Allelic Variants Exhibit Different Substrate Specificities.

ABSTRACT: Staphylococcus aureus is an opportunistic pathogen that is persistently colonizing nearly 30% of the human population and can cause life-threatening infections. S. aureus secretes a variety of virulence factors, such as a set of extracellular serine protease-like proteins (Spls). Spls are expressed by most clinical isolates of S. aureus, but their pathophysiological substrates and role during infection are largely unknown. Pathogens use allelic variation of virulence factors to allow an adaption to different host cells and their defense mechanisms. The differences of these variants are marginally characterized so far. Here, we performed a biochemical characterization of selected allelic variants of the S. aureus SplA and SplB. Our data suggests different variants show differences in their

SUBMITTER: Glinka FL 

PROVIDER: S-EPMC12783888 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature