Inhibitory circuit motifs of cortical somatosensory layer 5 SST interneurons are uniform within layers but specific across layers.

ABSTRACT: Layer (L) 5 is a hub in the cortical column in which a multitude of feedforward and feedback pathways converge. These inputs are then transmitted to distant sites by resident pyramidal neurons (PN). L5 PN are under the strong influence of local somatostatin (SST)-expressing interneurons (IN). To better understand the inhibitory control of L5 SST cells, which leads to disinhibition of excitatory cells, we used paired whole-cell patch-clamp recordings in acute brain slices. We investigated whether they receive intra- and translaminar inputs by parvalbumin (PV) and vasoactive intestinal polypeptide (VIP) IN and what type of short-term synaptic plasticity these inputs display. In triple transgenic mice we found that intralaminarly both PV and VIP IN effectively target L5 SST IN. PV to SST conn

SUBMITTER: Preuss F 

PROVIDER: S-EPMC12783935 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature