Adherence to Protocol Registration Among Systematic Reviews on Photobiomodulation: A Meta-Research Study.

ABSTRACT:

Aims and objectives

This meta-research study mapped systematic reviews on photobiomodulation (PBM), encompassing low-level laser therapy (LLLT) and light-emitting diode (LED) modalities, to evaluate whether protocols were registered, whether published reviews adhered to and updated their PROSPERO records, and whether topic redundancy occurred across reviews.

Methods

Comprehensive searches were conducted in MEDLINE (via PubMed) and Epistemonikos on June 2, 2025. Data were extracted on protocol registration, registry type, update status on PROSPERO, deviations between registered protocols and published reviews, topic redundancy, and the use of certainty of evidence assessment tools.

Results

A total of 285 systematic reviews (with and without meta-analysis) published bet

SUBMITTER: Santos GM 

PROVIDER: S-EPMC12783942 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature