Maternal obesity during pregnancy disrupts iron homeostasis and promotes fetal hypoxia in the mouse.

ABSTRACT: Research in both humans and animals has consistently demonstrated that diverse complications during pregnancy impact on the risk of chronic diseases in the offspring. In many settings, over half of women are either overweight or living with obesity during pregnancy. This has short- and long-term impacts on offspring health. The mechanisms mediating changes in the fetal environment that may trigger developmental origins of future cardiometabolic risk in the offspring are not fully elucidated. In this study, using an established mouse model, we aimed to determine whether obesity during pregnancy causes fetal hypoxia and to explore potential underlying mechanisms. We showed that fetal hypoxia is a key component of the in utero obesogenic environment at E13.5/0.7 of gestation. Concomitantly, o

SUBMITTER: Cordova-Casanova A 

PROVIDER: S-EPMC12783957 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature