Inhaled Ciclesonide for Community-Based COVID-19: A Placebo-Controlled Randomised Trial.

ABSTRACT:

Background and objectives

Inhaled corticosteroids have been proposed as treatment for acute COVID-19 infection in the community. We sought to determine the efficacy and safety of inhaled ciclesonide 320 mcg daily for 14 days compared to placebo in reducing the time to first recovery from all symptoms within 28 days of randomisation.

Methods

We conducted a two-arm, double blind, placebo-controlled, community-based randomised trial. Participants received inhaled ciclesonide 320 mcg daily or matching placebo for 14 days. The primary outcome was time to recovery of symptoms to day 28. An updated systematic review of all controlled trials of inhaled corticosteroids for acute COVID-19 was then undertaken.

Results

There were 189 people randomised and 185 completed treatment;

SUBMITTER: Wark P 

PROVIDER: S-EPMC12783969 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature