Acid-sensing ion channel 1a deficiency drives endocrine hypertension in male mice.

ABSTRACT: Acid-sensing ion channel 1a (ASIC1a) is a proton-gated cation channel activated by extracellular acidosis, a condition often associated with ischaemia, inflammation and metabolic stress. Our laboratory has previously demonstrated that ASIC1a contributes to systemic endothelium-dependent vasodilatation; however, the role of ASIC1a in blood pressure regulation remains unclear. The objective of this study was to investigate the role of ASIC1a in blood pressure regulation using a model of angiotensin II-induced hypertension. We further determined the effects of age and sex, as these are non-modifiable risk factors for hypertension. Radiotelemeters were implanted in 6- and 18-month-old male and female wild-type (Asic1a^+/+) and ASIC1a knockout (Asic1a^-/-) mice to continuous

SUBMITTER: Garcia SM 

PROVIDER: S-EPMC12783972 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature