Generalised Hodgkin-Huxley model captures human P2X and AMPA receptor currents.

ABSTRACT: Ionotropic receptors are transmembrane ion channels that play central roles in regulating synaptic transmission in the nervous system and cellular activity underlying immune responses. However, a unified mathematical model capturing their dynamics remains elusive. In this paper a generalised Hodgkin-Huxley (gHH) model is introduced, which seamlessly represents different activation, inactivation and recovery dynamics of the entire human P2X receptor family and the human AMPA-type glutamate receptor. The model incorporates two activation gates (m₁, m₂) and two inactivation gates (h₁, h₂) to connect electrophysiological recordings to the underlying kinetics of ligand-gated receptor currents beyond voltage-gated channels. We propose five distinct for

SUBMITTER: Poshtkohi A 

PROVIDER: S-EPMC12783981 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature