T-Cell Immune Dysfunction and Progression to Severe COVID-19 in Asthma Revealed by Single-Cell RNA Sequencing.

ABSTRACT:

Background

Little information is available on the immune signaling pathway that drives severe coronavirus disease 2019 (COVID-19) in asthma. Our study uses single-cell RNA sequencing (scRNA-seq) to evaluate the association between immune dysfunction and progression to severe COVID-19 in asthma.

Methods

Four patients with asthma and eight patients without asthma from three centers in South Korea were analyzed. Samples were collected from each patient over three-time points: at the time of COVID-19 infection, 1 week later, and 2 weeks later.

Results

Patients were classified into four groups according to the presence or absence of asthma and COVID-19 severity: non-asthma/mild COVID-19 (n=5), non-asthma/severe COVID-19 (n=3), asthma/mild COVID-19 (n=3), and asthma/severe

SUBMITTER: Kim BG 

PROVIDER: S-EPMC12784130 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature