TNF/TNFR1 is a Key Regulator of Prolonged Fasting-Induced Decrease in Adipose Tissue.

ABSTRACT: Nutrient availability influences white adipose tissue (WAT) inflammation, leading to decreased or increased adiposity. Tumor necrosis factor (TNF) is elevated in WAT under both conditions, being involved in lipolysis and regulation of interleukin 18 (IL-18) secretion, which may regulate lipolytic processes. However, the role of these cytokines in adiposity reduction due to low energy availability remains unclear. Wild-type (WT) mice fasted for 24 h showed decreased adiposity, whereas TNFR1 knockout mice (TNFR1^-/-) were unresponsive to fat pad loss, even after 48-h fasting. TNFR1^-/- mice were also resistant to β3-adrenergic receptor agonist CL316,243-induced fat mobilization, which was linked with reduced expression of lipases, β3-adrenergic receptors, and cytokines in

SUBMITTER: de Oliveira ACC 

PROVIDER: S-EPMC12784137 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature