<i>Astragalus membranaceus</i>-<i>Salvia miltiorrhiza</i> Decoction Ameliorates Metabolic Syndrome and Gut Microbiota Dysbiosis Induced by High-Fat Diet: A Comparative Study.

ABSTRACT: Astragalus membranaceus (Fisch.) Bunge (AM)-Salvia miltiorrhiza Bunge (SM) decoction (ASD) is a herb pair not only widely used in clinic against cardiovascular diseases and metabolic syndrome, but also as key compositions in some functional foods. However, the pairing ratios and potential mechanisms of ASD in preventing metabolic syndrome are still unclear. The present study comprehensively evaluated how the pairing ratios of AM and SM affect the treatment of ASD against high-fat diet (HFD)-induced metabolic disorder and investigate the roles of gut microbiota in the biological process. To establish a metabolic syndrome model, thirty SD male rats received a 10-week HFD. All rats were divided into six groups randomly: ND, HFD, ASD-A (the quality ratio of 1:2 AM to SM), ASD-B (

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12784168 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature