Disruption of the l-DOPA Receptor Gpr143/OA1-Gene in Mice Creates a Unique Mixed Psychosis-Like Phenotype.

ABSTRACT: GPR143, originally identified as the gene product of ocular albinism 1 (OA1), a G protein-coupled receptor (GPCR), can function as a receptor for l-3,4-dihydroxyphenylalanine (DOPA), a precursor of dopamine (DA). To examine the physiological and pathophysiological roles of GPR143, we analyzed the behavior of Gpr143 gene-deficient (Gpr143^-/y) mice. We performed comprehensive behavioral analyses including the prepulse inhibition test, sucrose preference test, light-dark exploration test, etc. and microarray analysis. Gpr143^-/y mice displayed a mixed psychosis-like phenotype: impaired prepulse inhibition (a characteristic of schizophrenia) combined with reward system aberrations, depression, and heightened aggression (characteristic of mood disorders). By microarray anal

SUBMITTER: Goshima Y 

PROVIDER: S-EPMC12784213 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature