Locus coeruleus alterations in dementia with Lewy bodies: A systematic review.

ABSTRACT:

Introduction

The locus coeruleus (LC) is a small nucleus located deep within the brainstem, serving as the brain's main source of noradrenergic neurons. Through its extensive projections, it plays a critical role in regulating cognitive processes and arousal. Although LC degeneration has been well documented in Alzheimer's disease and Parkinson's disease, its specific involvement in the pathophysiology of dementia with Lewy bodies (DLB) remains poorly understood.

Methods

This systematic review, conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, explores the role of LC in the pathogenesis of DLB by synthesizing findings from human neuropathological and neuroimaging research and animal models of α-synucleino

SUBMITTER: Bain A 

PROVIDER: S-EPMC12784214 | biostudies-literature | 2026 Jan-Mar

REPOSITORIES: biostudies-literature