Risk of Household Secondary Invasive Group A Streptococcal Infections After a Prophylaxis Policy Change.

ABSTRACT:

Importance

Household contacts of patients with invasive group A streptococcus (iGAS) disease have an increased risk of iGAS. In the Netherlands, the iGAS public health policy was changed in January 2023, offering antibiotic prophylaxis to household contacts of all patients with iGAS rather than only those presenting with necrotizing fasciitis or streptococcal toxic shock syndrome.

Objective

To estimate risk of iGAS in the general population and among household and other contacts of primary patients with iGAS, before and after the policy change.

Design, setting, and participants

This nationwide, population-based, open cohort study, linked population registry data with iGAS laboratory data for the study period (April 2022 to December 2024). The study population consiste

SUBMITTER: de Gier B 

PROVIDER: S-EPMC12784225 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature