Specificity of Polygenic Scores for Psychiatric Disorders Beyond Transdiagnostic Genetic Risk.

ABSTRACT:

Importance

Polygenic scores (PGSs) are increasingly used to estimate genetic liability for psychiatric disorders, but their limited disorder specificity constrains their clinical and research utility.

Objective

To test whether associations between psychiatric PGSs and psychiatric outcomes are primarily driven by transdiagnostic or disorder-specific genetic liability.

Design, setting, and participants

This cohort study used a population-based sample from the Twins Early Development Study of twins born in England and Wales between January 1994 and December 1996. Mental health data were collected from July 2021 through June 2023, when participants were aged 25 to 28 years. The analyses include participants who had available genetic data and at least 1 quantitative sympto

SUBMITTER: Keser E 

PROVIDER: S-EPMC12784231 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature