Endothelial CEPT1 Promotes Angiogenesis Through PPARα and VEGF-A Signaling.

ABSTRACT:

Background

Cept1 is essential for de novo phopholipogenesis and is impacted by diabetes. We previously demonstrated that conditional knockdown of Cept1 in the endothelium leads to reduced tissue recovery. Therefore, we hypothesized that Cept1 overexpression may also be sufficient in promoting postischemic angiogenesis and recovery in the setting of diabetes.

Methods

CEPT1 (choline-ethanolamine phosphotransferase 1) content was evaluated in the peripheral arteries of human patients with peripheral artery disease and with or without diabetes. We also engineered a conditional endothelial cell (EC)-specific Cept1 overexpression mouse (Cept1^fl/fl Cre⁺) in adult C57BL/6J (C57 black 6J) mice and performed unilat

SUBMITTER: Khan TJ 

PROVIDER: S-EPMC12784299 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature