Eyring-Polanyi Rate Theory for the Homogeneous Nucleation of Organic Crystals from Solution.

ABSTRACT: Using elementary concepts of chemical reaction kinetics, the rates of primary homogeneous organic crystal nucleation from supersaturated solutions are modeled as nucleation with first order kinetics from large solute density fluctuations (LSDFs). Solute density fluctuations are modeled as diffusively driven many-body collisions of weakly interacting solvated solute molecules. The first order rate constant is a system-specific supersaturation-independent rate constant for nucleation in LSDFs. It is shown for several solute-solvent systems that the temperature-dependence of this nucleation rate constant exhibits Arrhenius behavior. The activation enthalpy (ΔH ^⧧) and activation entropy (ΔS ^⧧) for homogeneous nucleation is determined from an Eyring-Polanyi a

SUBMITTER: Schroeder SLM 

PROVIDER: S-EPMC12784332 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature