Human TRPV1 Channels are Functional Allosteric Receptors for Ciguatoxins and Brevetoxins.

ABSTRACT: Ciguatera poisoning (CP) is a foodborne illness caused by the consumption of seafood containing ciguatoxins (CTXs). There is a wide variety of symptoms associated with ciguatera poisoning; however, the origin and physiological cause of many of them remains still unclear. Although the primary effect of ciguatoxins and brevetoxins (BTX) is their effect in voltage-gated sodium channels, in this work, the effect of both toxins on human transient receptor potential vanilloid 1 (TRPV1) channels was investigated under different physiological conditions that may contribute to CP. The results obtained showed that different physiological conditions that may occur in the organism potentiated the effect of ciguatoxins on TRPV1. Among these conditions, low pH, the presence of oxidative stress products,

SUBMITTER: Rodriguez-Rodriguez U 

PROVIDER: S-EPMC12784398 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature