Automated closed-loop continuous flow block copolymer synthesizer.

ABSTRACT: A fully automated continuous flow synthesizer for diblock copolymer (BCP) synthesis was constructed comprising elements of flow chemistry, automation, machine learning and in-line monitoring. A new method using in-line FTIR spectroscopic analysis for accurate determination of monomer conversion (with an error as low as 2% relative to an NMR spectroscopic baseline) is presented, thereby generating a reliable feedback system for reaction self-optimisation using the platform. By employing reversible addition-fragmentation chain transfer (RAFT) polymerization at 100 °C, acrylates and acrylamides of different hydrophilicities (namely methyl acrylate, ethyl acrylate, butyl acrylate, 2-ethylhexyl acrylate, 2-hydroxyethyl acrylate, ethylene glycol methyl ether acrylate, diethylene glycol ethyl eth

SUBMITTER: Wong WN 

PROVIDER: S-EPMC12784417 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature