Efficient one-pot quinoline derivative synthesis from acetophenone and allyl alcohols.

ABSTRACT: Quinoline derivatives are widely found in pharmaceuticals, agrochemicals, and functional materials, and the development of efficient synthetic methods for these compounds has attracted considerable attention. In this study, we reported a strategy employing O-sulfonylhydroxylamine (HOSA) as a novel transient directing group (TDG) to achieve site-selective ortho C-H functionalization/cyclization of acetophenones with allyl alcohols. This reaction system operated under mild and readily tunable conditions, enabling efficient construction of the quinoline scaffold via a one-pot process. Our investigations revealed that the structure of the transient directing group, solvent, and reaction temperature collectively govern the reaction pathway, allowing precise control over pro

SUBMITTER: Zeng F 

PROVIDER: S-EPMC12784452 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature