Repeatability of in vivo MR cytometry for measuring cell size and density in healthy human livers.

ABSTRACT:

Purpose

To evaluate the repeatability of MRI-derived cell size and density measurements in the healthy human liver using MR cytometry, a non-invasive technique for quantifying tissue microstructure, METHODS: Eight healthy subjects underwent two identical MR cytometry scans (2-7 days apart) on a Phillips 3 T scanner. Diffusion data were acquired using pulsed gradient spin echo (PGSE) and oscillating gradient spin echo (OGSE) sequences at multiple diffusion times. Bayes factor model selection compared different MR cytometry signal models, such as IMPULSED, which ignores water exchange between intra and extracellular compartments, and JOINT, which accounts for it. Repeatability of MRI-derived parameters were assessed via whole-volume and multi-size ROI analyses using Bland-Altman plot

SUBMITTER: Jiang X 

PROVIDER: S-EPMC12784474 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature