Novel urinary biomarkers to differentiate AKI etiologies and predict mortality in decompensated cirrhosis patients: a prospective cohort study.

ABSTRACT:

Introduction

The differentiation of causes of Acute Kidney Injury (AKI) in decompensated chronic liver disease (DCLD) presents a diagnostic challenge. This study aims to evaluate the diagnostic and prognostic utility of Neutrophil gelatinase-associated lipocalin (NGAL), Kidney injury molecule-1 (KIM-1), and interleukin-18 (IL-18) in cirrhotic patients with AKI.

Methods

This prospective cohort study was conducted at a tertiary care hospital in northeast India. Patients (n = 100) were divided into cases comprising decompensated cirrhosis with AKI (n = 50) and controls comprising decompensated cirrhosis without AKI (n = 50). Cases included patients with acute tubular necrosis (ATN) (n = 10), hepatorenal syndrome (HRS) (n = 18), and prerenal azotemia (PRA) (n = 22). Urinary NGAL

SUBMITTER: Phukan C 

PROVIDER: S-EPMC12784513 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature