MicroRNA dysregulation in cow's jejunum, jejunal lymph node, and caecal Peyer's patch during Mycobacterium avium subsp. paratuberculosis infection.

ABSTRACT: Mycobacterium avium subsp. paratuberculosis (MAP) is responsible for Johne's disease (JD), a contagious granulomatous gastroenteritis with global distribution. This study investigated the expression of miRNAs and their potential regulatory mechanisms in Canadian Holstein cows with different MAP infection status, including 4 infected (MAPI), 5 tolerant to MAP infection (MAPT) and 5 healthy controls (HC).Intestinal tissues, jejunum (JE), jejunal lymph node (JELN) and caecal Peyer's patches (CPP) were collected for miRNA-sequencing, differential expression and functional analysis. A total of 318, 281 and 251 miRNAs were identified in JE, JELN, and CPP, respectively. Out of these, 28, 46, and 24 were highly expressed in JE, JELN and CPP, respectively, including 23 miRNAs highly expressed acros

SUBMITTER: Wang M 

PROVIDER: S-EPMC12784533 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature