Electroacupuncture ameliorates incisional pain via suppressing IL-33 signaling-related macrophage infiltration and ROS overproduction in incised skin.

ABSTRACT:

Background

Postoperative pain develops after surgical operation. Inadequately managed postoperative pain is oftentimes associated with deterioration in life quality and delayed rehabilitation. Clinical studies confirmed analgesic effects of acupuncture on patients with postoperative pain. We hereby explored mechanisms underlying how acupuncture alleviates postoperative pain.

Methods

A mouse model of skin incision-induced pain was established to mimic postoperative pain condition. Electroacupuncture (EA) or sham EA was administered at ST36 and BL60 acupoints in model mice. A combination of RNA-Sequencing (RNA-Seq), immunostaining, biochemical assay, in vivo imaging and behavioral test were applied for mechanism investigations.

Results

2/100 Hz EA intervention ameliorat

SUBMITTER: Xu R 

PROVIDER: S-EPMC12784544 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature