A prospective clinical evaluation of new ECCO2R technology in mild to moderate ARDS patients: assessing ultra-lung-protective ventilation with PRISMALUNG.

ABSTRACT:

Background

Extracorporeal carbon dioxide removal (ECCO₂R), when used as an adjunct to mechanical ventilation in patients with mild to moderate acute respiratory distress syndrome (ARDS), has been proposed as a strategy to control hypercapnic acidosis during ultra-lung-protective ventilation (ULPV). However, no multicenter study has systematically assessed ventilation improvement markers with a standardized protocol using ECCO₂R devices featuring a peristaltic pump design. This prospective, multicenter study conducted in France addresses these gaps by evaluating the performance and safety of PRISMALUNG+, a novel membrane lung specifically developed for ECCO₂R, either as a standalone therapy or combined with continuous renal replacement therapy (CRRT). A specifi

SUBMITTER: Combes A 

PROVIDER: S-EPMC12784554 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature