Modified Shen-Yan-Fang-Shuai formula attenuates diabetic kidney disease progression via regulation of HIF-1α-mediated mitochondrial energy metabolism.

ABSTRACT:

Background

Diabetic kidney disease (DKD) represents a major global health burden, affecting 20-40% of diabetic patients worldwide. Metabolic reprogramming mediated by hypoxia-inducible factor-1α (HIF-1α) plays a central role in DKD pathogenesis, yet effective therapeutic strategies remain limited. The Modified Shen-Yan-Fang-Shuai formula (M-SYFSF), a traditional Chinese medicine formulation, has demonstrated clinical efficacy in DKD treatment, but its underlying mechanisms remain unclear.

Methods

A DKD model was established using streptozotocin-induced diabetic rats following unilateral nephrectomy. Thirty rats were randomly divided into sham operation, model, and M-SYFSF treatment groups (n = 10/group). M-SYFSF was administered at 11.34 g/kg/d for 12 weeks. Renal function,

SUBMITTER: Di B 

PROVIDER: S-EPMC12784558 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature