Mortality effect of higher versus lower blood pressure targets in vasodilatory shock: an updated systematic review and meta-analysis.

ABSTRACT:

Objective

To determine the impact of higher versus lower mean arterial pressure (MAP) targets on mortality and other outcomes in patients with vasodilatory shock.

Design

A systematic review and meta-analysis of randomised controlled trials (RCTs) following PRISMA guidelines with the protocol preregistered with PROSPERO (CRD420251087844).

Data sources

PubMed, Embase, CENTRAL, and Scopus from their inception until July 2025.

Methods

This review included RCTs that compared a higher MAP target arm, typically 80±5 mmHg or the physiologically higher target arm within the trial, to a lower target arm (generally 65±5 mmHg) in adult patients with vasodilatory shock. The primary outcome was all-cause mortality. The analysis utilised random-effects models, subgroup analys

SUBMITTER: Mendes H 

PROVIDER: S-EPMC12784574 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature