Rhapontigenin alleviates cellular senescence and physiological aging by upregulating sirt1 and promoting autophagy.

ABSTRACT:

Background

Aging is characterized by cellular senescence, inflammation, and physiological decline. Currently available antiaging therapies often have limitations due to their toxicity and off-target effects. However, natural compounds derived from Chinese herbal medicine, such as Rhapontigenin (Rhap), have shown potential as safer antiaging agents.

Purpose

This study aimed to evaluate the potential of Rhap to be used as an antiaging agent by investigating its effects on cellular senescence, physical function, immune modulation, and autophagy in both in vitro and in vivo aging models.

Methods

NIH3T3 and IMR90 cells were subjected to oxidative or genotoxic stress to induce senescence and then treated with Rhap. Senescence markers, cell viability, and autophagy-related p

SUBMITTER: Liu S 

PROVIDER: S-EPMC12784611 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature